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徐振林

发布时间:2017-04-19 23:33:30文章来源:华南农业大学食品学院浏览次数:507


青年教授,博士生导师



电话:020-8528344813570552215
E-mail
jallent@163.com
办公室:食品学院521
邮编:510642


徐振林,男,青年教授,博士生导师,广东省自然科学杰出青年基金获得者,广东省特支计划科技创新青年拔尖人才,广东省高等学校优秀青年教师计划入选者,广州市珠江科技新星。主要从事食品及环境中小分子化学有害物检测技术研究与应用,主持国家自然科学基金、中国博士后基金特别资助项目、广东省科技计划等课题10多项,主要参加国家973课题、863计划等课题多项。

近年来在国际权威期刊发表SCI论文70多篇,其中以第一作者或通讯作者发表SCI论文29篇,累计影响因子93.2;申报专利33项,获授权21项;获得国家科技进步二等奖、国家教学成果二等奖、广东省科学技术一等奖、中华农业科技二等奖各1项。博士学位论文“有机磷农药多特异性抗体识别机制与多残留免疫检测新方法研究”获得2013年全国百篇优秀博士学位论文提名奖。现为SCI期刊J. Environ. Sci. Health, Part B编委,J. Agric. Food Chem., Food Control, Food Agric. Immunol., 分析测试学报等杂志审稿人。


教育背景和工作经历

教育背景:

2000-2004 华南农业大学食品科学与工程专业 学士;

2004-2007华南农业大学食品科学专业 硕士;

2007-2011 华南农业大学食品科学 博士。

工作经历:

2011-2012 中国科学院华南植物园 分子生物学专业 博士后;

2013- 华南农业大学食品学院 副研究员/青年教授;

2015- 2016加州大学戴维斯分校 访问


开设课程

本科课程:
《食品分析》、《食品与发酵工业分析》、《食品营养学》;
研究生课程:
《食品分析检测新技术》、《天然产物化学合成与分离研究进展》


主要研究方向和科研项目

研究方向:

食品质量安全快速检测与控制

科研项目:

[1]广东省自然科学杰出青年基金,基于重组蛋白晶体结构的抗体-小分子识别机制研究与应用,2014A0303060262015/1-2018/12,在研,主持
[2]
广东省科技计划项目,酱油酿造过程中有害物氨基甲酸乙酯的快速检测与控制技术研究,2015B0202050022015/5-2018/4,在研,主持
[3]
广东省特支计划青年科技创新拔尖人才项目,2014TQ01N1092015/4-2018/9,在研,主持       

[4] 广东省高等学校优秀青年教师培养计划,食品中小分子组胺特异性抗体制备、识别机制研究与应用,Y920/40262015/1-2017/12,在研,主持    

[5] 国家自然科学基金项目青年项目,二乙氧基硫代磷酸酯类农药多特异性单链抗体识别机制及其定向进化,313014672014/01-2016/12,结题,主持       

[6] 广州市“珠江科技新星”项目(人才项目),基于结构导向的有机磷农药多特异性单链抗体性能改造,2014/01-2016/12,在研,主持       

[7] 广东省高等学校学科与专业建设专项资金(科技创新项目),食品加工中新

[8] 中国博士后科学基金第5批特别资助项目,小分子有害物多残留免疫检测中的抗体识别机制研究,2012T507352011/06-2012/12,结题,主持       

[9] 国家973课题,食品加工全过程多源安全在线检测与预警体系,2012CB7208032012/01-2016/12,在研,参与      

[10] 国家自然科学基金面上项目,硝基呋喃代谢物多价半抗原的抗体诱导及抗体与代谢物原型识别机制研究,312718652013/1-20116/12,在研,参与        

[11]十三五国家重点研发计划-政府间国际科技创新合作重点专2016YFE0106000,基于纳米抗体的食品安全快速检测技术及产品研究,2016/12-2019/12,在研,参与


发表论文

[1]Yong-Fang Li, Yuan-Ming Sun, Ross C. Beier, Hong-Tao Lei*, Shirley Gee, Bruce D. Hammock, Hong Wang, Zhanhui Wang, Xiulan Sun, Yu-Dong Shen, Jin-Yi Yang, Zhen-Lin Xu*. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: A review. Trends in Analytical Chemistry 88 (2017) 25-40.

[2]Hui-Jun Fu, Yu Wang, Xiu-Xiu Dong, Yi-Xin Liu, Zi-Jian Chen, Yu-Dong Shen, Chi Yang, Jie-Xian Dong and Zhen-Lin Xu*. Application of nickel cobalt oxide nanoflakes for electrochemical sensing of estriol in milk. RSC Adv., 2016, 6, 6558865593.

[3]Lin Luo, Hong-Tao Lei, Jin-Yi Yang, Gong-Liang Liu, Yuan-Ming Sun*, Wei-Dong Bai, Hong Wang, Yu-Dong Shen, Sui Chen, Zhen-Lin Xu*. Development of an indirect ELISA for the determination of ethyl carbamate in Chinese rice wine. Analytica Chimica Acta, 950, ( 2017), Pages 162169

[4]Haopeng Zeng, Jiahong Chen, Chijian Zhang, Xin-an Huang,*, Yuanming Sun, Zhenlin Xu,* and Hongtao Lei*. Broad-Specificity Chemiluminescence Enzyme Immunoassay for (Fluoro)quinolones: Hapten Design and Molecular Modeling Study of Antibody Recognition. Anal. Chem. 2016, 88, 39093916

[5]Jiahong Chen, Ning Lu, Xing Shen, Qiushi Tang, Chijian Zhang, Jun Xu, Yuanming Sun, Xin-an Huang,* Zhenlin Xu,* and Hongtao Lei*. Investigation of an Immunoassay with Broad Specificity to Quinolone Drugs by Genetic Algorithm with Linear Assignment of Hypermolecular Alignment of Data Sets and Advanced Quantitative StructureActivity Relationship Analysis. J. Agric. Food Chem. 2016, 64, 27722779

[6]Xiu-xiu Dong, Yi-xin Liu, Yuan-ming Sun, Chi Yang*, Zhen-lin Xu*. In situ growth of microporous ZnO nanorods end surfaces on indium tin oxides (ITO): facile synthesis and their application as selective electrocatalyst for dopamine oxidization. Materials Letters, 2016, 162, 246249 (SCI, 2014IF=2.489,工程技术二区)

[7] Xiu-xiu Dong, Mei-ying Li, Nan-nan Feng, Yuan-ming Sun, Chi Yang*and Zhen-lin Xu*. A nanoporous MgO based nonenzymatic electrochemical sensor for rapid screening of hydrogen peroxide in milk. RSC Advance, 2015, 5, 8648586489

[8] Lin Luo, Jin-Yi Yang, Zhi-Li Xiao,Dao-Ping Zeng, Yong-Jun Li,Yu-Dong Shen,Yuan-Ming Sun,*Hong-Tao Lei, Hong Wang and Zhen-Lin Xu*. A sensitivity-enhanced heterologous immunochromatographic assay based on a monoclonal antibody for the rapid detection of histamine in saury samples. RSC Advance, 2015, 5, 7883378840

[9] Lin Luo,# Zhen-Lin Xu,# Jin-Yi Yang, Zhi-Li Xiao, Yong-Jun Li, Ross C. Beier, Yuan-Ming Sun,* Hong-Tao Lei, Hong Wang, and Yu-Dong Shen*. Synthesis of novel haptens and development of an enzyme-linked immunosorbent assay for quantification of histamine in Foods. Journal of Agricultural and Food Chemistry, 2014, 62, 1229912308

[10] Lin Luo, Yu-Dong Shen, Hong Wang, Zhi-Li Xiao, Yuan-Ming Sun*, Hong-Tao Lei, Jin-Yi Yang, Zhen-Lin Xu*. Production of polyclonal antibody and development of a competitive enzyme-linked immunosorbent assay for benzoic acid in foods. Food Analytical Methods, 2015, 8, 1101-1111

[11] Jing Wu, Yu-Dong Shen, Hong-Tao Lei, Yuan-Ming Sun*, Jin-Yi Yang, Zhi-Li Xiao, Hong Wang, and Zhen-Lin Xu*. Hapten synthesis and development of a competitive indirect enzyme-linked immunosorbent assay for acrylamide in food samples. Journal of Agricultural and Food Chemistry, 2014, 62, 70787084

[12] Zhen-Lin Xu, Shi-Wei Zhang, Yuan-Ming Sun, Yu-Dong Shen*, Hong-Tao Lei, Yue-Ming Jiang, Sergei A. Eremin, Jin-Yi Yang, Hong Wang. Monoclonal antibody-based fluorescence polarization immunoassay for high-throughput screening of furaltadone and its metabolite AMOZ in animal feeds and tissues. Combinatorial Chemistry & High Throughput Screening, 2013, 16(6), 494 502 

[13] Zhen-Lin Xu, Yu-Dong Shen, Yuan-Ming Sun, Katrina Campbell, Yuan-Xin Tian, Shi-Wei Zhang, Hong-Tao Lei, Yue-Ming Jiang*. Novel hapten synthesis for antibody production and development of an enzyme-linked immunosorbent assay for determination of furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ). Talanta, 2013, 103, 306313

[14] Zhen-Lin Xu, Hao Deng, Xing-Fei Deng, Jin-Yi Yang, Yue-Ming Jiang, Dao-Ping Zeng, Fang Huang, Yu-Dong Shen, Hong-Tao Lei, Hong Wang, Yuan-Ming Sun*. Monitoring of organophosphorus pesticides in vegetables using monoclonal antibody-based direct competitive ELISA followed by HPLCMS/MS. Food Chemistry , 2012, 131(4), 15691576 9

[15] Zhen-Lin Xu, Wen-Jia Sun, Jin-Yi Yang, Yue-Ming Jiang, Katrina Campbell, Yu-Dong Shen, Hong-Tao Lei, Dao-Ping Zeng, Hong Wang, Yuan-Ming Sun*. Development of a solid-phase extraction coupling chemiluminescent enzyme immunoassay for determination of organophosphorus pesticides in environmental water samples. Journal of Agricultural and Food Chemistry, 2012, 60(9), 20692075

[16] Zhen-Lin Xu, Jie-Xian Dong, Hong Wang, Zhen-Feng Li, Ross C. Beier, Yue-Ming Jiang, Hong-Tao Lei, Yu-Dong Shen, Jin-Yi Yang, Yuan-Ming Sun*. Production and characterization of a single-chain variable fragment linked alkaline phosphatase fusion protein for detection of O,O-diethyl organophosphorus pesticides in a one-step enzyme-linked immunosorbent assay. Journal of Agricultural and Food Chemistry, 2012, 60(20), 50765083.

[17] Zhen-Lin Xu, Hao Deng, Hong-Tao Lei, Yue-Ming Jiang, Katrina Campbell, Yu-Dong Shen, Jin-Yi Yang, Hong Wang, Yuan-Ming Sun*. Development of a broad-specificity monoclonal antibody-based immunoaffinity chromatography cleanup for organophosphorus pesticide determination in environmental samples. Journal of Agricultural and Food Chemistry, 2012, 60(23), 58475852

[18] Zhen-Lin Xu, Jie-Xian Dong, Jin-Yi Yang, Hong Wang, Yue-Ming Jiang, Hong-Tao Lei, Yu-Dong Shen, Yuan-Ming Sun*. Development of a sensitive time-resolved fluoroimmunoassay for organophosphorus pesticides in environmental water samples. Analytical Methods, 2012, 4(10), 34843490 

[19] Zhen-Lin Xu, Qiang Wang, Hong-Tao Lei, Sergei A. Eremin, Yu-Dong Shen, Hong Wang, Ross C. Beier, Jin-Yi Yang, Ksenia A. Maksimova, Yuan-Ming Sun*. A simple, rapid and high-throughput fluorescence polarization immunoassay for simultaneous detection of organophosphorus pesticides in vegetable and environmental water samples, Analytica Chimica Acta, 2011, 708(1-2), 123129

[20] Zhen-Lin Xu, Hong Wang, Yu-Dong Shen, Mikaela Nichkov, Hong-Tao Lei, Ross C. Beier,Wen-Xu Zheng, Jin-Yi Yang, Zhi-Gang She, Yuan-Ming Sun*. Conformational changes of hapten-protein conjugates resulting in improved broad-specificity and sensitivity of an ELISA for organophosphorus pesticides, Analyst, 2011, 136(12), 25122520

[21] Zhen-Lin Xu, Dao-Ping Zeng, Jin-Yi Yang, Yu-Dong Shen, Ross C. Beier, Hong-Tao Lei, Hong Wang, Yuan-Ming Sun*. Monoclonal antibody-based broad-specificity immunoassay for monitoring organophosphorus pesticides in environmental water samples. Journal of Environmental Monitoring, 2011, 13(11), 30403048 

[22] Zhen-Lin Xu, Yu-Dong Shen, Wen-Xu Zheng, Ross C. Beier, Gui-Mian Xie, Jie-Xian Dong, Jin-Yi Yang, Hong Wang, Hong-Tao Lei, Zhi-Gang She, Yuan-Ming Sun*. Broad-specificity immunoassay for O,O-diethyl organophosphorus pesticides: application of molecular modeling to improve assay sensitivity and study antibody recognition. Analytical Chemistry, 2010, 82(22), 93149321

[23] Zhen-Lin Xu, Yu-Dong Shen, Ross C. Beier, Jin-Yi Yang, Hong-Tao Lei, Hong Wang, Yuan-Ming Sun*. Application of computer-assisted molecular modeling for immunoassay of low molecular weight food contaminants: a review. Analytica Chimica Acta, 2009, 647(2), 125136

[24] Zhen-Lin Xu, Gui-Mian Xie, Yong-Xiang Li, Bing-Feng Wang, Ross C. Beier, Hong-Tao Lei, Hong Wang, Yu-Dong Shen, Yuan-Ming Sun*. Production and characterization of a broad-specificity polyclonal antibody for O,O-diethyl organophosphorus pesticides and a quantitative structure-activity relationship study of antibody recognition. Analytica Chimica Acta, 2009, 647(1), 9096

 

科研及教学奖励

[1] 有机磷农药多特异性抗体识别机制与多残留免疫检测新方法研究,全国百篇优秀博士学位论文提名奖,2013
[2]
农业食品中有机磷农药等残留快速检测技术与应用,国家科技进步二等奖,2010,排名第9
[3]
契合社会发展需要的食品质量与安全专业人才培养体系构建与实践,国家教学成果二等奖,2014,排名第9
[4]
农产品中有机磷农药及克伦特罗等残留快速检测技术与应用,广东省科学技术一等奖,2010,排名第15
[5]
有机磷农药及“瘦肉精”等残留快速检测技术与应用,中华农业科技奖二等奖,2009,排名第11

[6] 刘凤权,华秀德,徐振林,张存政,王利民,王弘,王鸣华,杨金易,刘媛,孙远明,刘贤金,农产品与环境中农药、重金属快速检测技术与产品,中国植物保护学会,科技进步,其他,2016.11.112016-YJ-1-02-R03

 

申请及授权专利

[1] 徐振林,沈玉栋,孙远明,刘凤银,肖治理,杨金易,雷红涛,王弘. 一种直接检测呋喃它酮代谢物AMOZ的树状半抗原、树状抗原及其应用. 授权发明专利,ZL201410154388.0,授权时间2016.6.1

[2] 徐振林,孙远明,罗林,沈玉栋,肖治理,杨金易,雷红涛,王弘. 一种组胺半抗原、人工抗原、抗体及其制备方法与应用. 发明专利,专利号ZL 201310197597.9,授权时间2015-09-30
     [3]
徐振林,孙远明,董秀秀,冯阳,杨金易,王弘,雷红涛,沈玉栋. 一种基于电流型免疫传感器的组胺快速检测仪. 实用新型专利,专利号ZL201520359705.2,授权时间 2015-09-30

[4]徐振林,孙远明,罗林,沈玉栋,雷红涛,杨金易,王弘. 一种氨基甲酸乙酯半抗原组合、人工抗原组合及其制备方法与应用,美国发明专利申请,PCT/CN2016/095543,申请时间2016-08-16

[5]徐振林,孙远明,罗林,沈玉栋,雷红涛,杨金易,王弘. 一种氨基甲酸乙酯半抗原组合、人工抗原组合及其制备方法与应用. 发明专利,CN2016106763443-1,申请时间2016-08-16

[6] 徐振林,罗林,孙远明,杨金易,雷红涛,王弘,沈玉栋,刘功良. 一种呫吨聚氨基甲酸乙酯的半抗原、人工抗原及其应用. 申请发明专利,CN201610675358.3,申请时间2016-8-16

[7]徐振林,陈子键,雷红涛,刘辉,王弘,孙远明,杨金易. 一种抗二乙氧基硫代磷酸酯类有机磷农药的Fab抗体及制备方法和应用. CN201611236387.6, 发明专利,申请时间2016.12.28

[8] 孙远明,徐振林,吴璟,沈玉栋,雷红涛,肖治理,王弘,杨金易. 一种丙烯酰胺半抗原、人工抗原、抗体及其制备方法与应用,发明专利,专利号:ZL 201310197570.X,授权时间2015-5-20
     [9]
孙远明,徐振林,王弘,雷红涛,李丽华,沈玉栋,杨金易,李振峰. 莱克多巴胺残留的时间分辨免疫分析检测试剂盒及其检测方法. 发明专利,专利号: ZL201010268992.8,授权时间2013-10-16
     [10]
孙远明,徐振林,沈玉栋,雷红涛,谢桂勉,王弘,杨金易. 二乙氧基硫代磷酸酯类有机磷农药半抗原及其制备方法. 发明专利,ZL200910036525.X,授权时间2011-11-16